7DT2: Strategic design of catalytic lysine-targeting reversible covalent BCR-ABL Inhibitors

PDB ID: 7DT2Download
MMDB ID: 202955
PDB Deposition Date: 2021/1/4
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 7DT2: monomeric; determined by author
Molecular Components in 7DT2
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase Abl1
(Gene symbol: ABL1)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
[4-[5-[5-(dimethylcarbamoyl)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-methanoyl-5-methoxy-phenyl]boronic acid[4-[5-[5-(dimethylcarbamoyl)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-methanoyl-5-methoxy-phenyl]boronic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303