7D9R: Structure of huamn soluble guanylate cyclase in the riociguat and NO-bound state

PDB ID: 7D9RDownload
MMDB ID: 205448
PDB Deposition Date: 2020/10/14
Updated in MMDB: 2021/10
Experimental Method:
electron microscopy
Resolution: 3.7  Å
Source Organism:
Similar Structures:
Biological Unit for 7D9R: dimeric; determined by author
Molecular Components in 7D9R
Label Count Molecule
Proteins (2 molecules)
1
Guanylate Cyclase Soluble Subunit Alpha-1
(Gene symbol: GUCY1A1)
Molecule annotation
1
Guanylate Cyclase Soluble Subunit Beta-1
(Gene symbol: GUCY1B1)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTERPHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
2
2
MAGNESIUM IONMAGNESIUM ION
3
1
PROTOPORPHYRIN IX CONTAINING FEPROTOPORPHYRIN IX CONTAINING FE
4
1
methyl ~{N}-[4,6-bis(azanyl)-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]-~{N}-methyl-carbamatemethyl ~{N}-[4,6-bis(azanyl)-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]-~{N}-methyl-carbamate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303