7D5B: BACE2 xaperone complex with N-{3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxo-5,6-dihydro-2H-1lambda6,2,4-thiadiazin-5-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide

PDB ID: 7D5BDownload
MMDB ID: 200414
PDB Deposition Date: 2020/9/25
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 1.31  Å
Source Organism:
Similar Structures:
Biological Unit for 7D5B: dimeric; determined by author and by software (PISA)
Molecular Components in 7D5B
Label Count Molecule
Proteins (2 molecules)
1
Beta-secretase 2
(Gene symbol: BACE2)
Molecule annotation
1
Xaperone
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
1
N-{3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamideN-{3-[(5R)-3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide
2
1
CHLORIDE IONCHLORIDE ION
3
3
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
2
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303