7CUM: Cryo-EM structure of human GABA(B) receptor bound to the antagonist CGP54626

PDB ID: 7CUMDownload
MMDB ID: 195161
PDB Deposition Date: 2020/8/23
Updated in MMDB: 2020/12
Experimental Method:
electron microscopy
Resolution: 3.52  Å
Source Organism:
Similar Structures:
Biological Unit for 7CUM: dimeric; determined by author
Molecular Components in 7CUM
Label Count Molecule
Proteins (2 molecules)
1
Gamma-aminobutyric Acid Type B Receptor Subunit 1
(Gene symbol: GABBR1)
Molecule annotation
1
Gamma-aminobutyric Acid Type B Receptor Subunit 2
(Gene symbol: GABBR2)
Molecule annotation
Chemicals and Non-standard biopolymers (19 molecules)
1
1
(R)-(cyclohexylmethyl)[(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid(R)-(cyclohexylmethyl)[(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid
2
2
UNKNOWN LIGANDUNKNOWN LIGAND
3
16
CHOLESTEROLCHOLESTEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303