7CTW: Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with fragment 820, NADPH, dUMP

PDB ID: 7CTWDownload
MMDB ID: 201447
PDB Deposition Date: 2020/8/20
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.51  Å
Source Organism:
Similar Structures:
Biological Unit for 7CTW: dimeric; determined by author and by software (PISA)
Molecular Components in 7CTW
Label Count Molecule
Proteins (2 molecules)
2
Bifunctional Dihydrofolate Reductase-thymidylate Synthase
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2
1
1-(2-methylsulfanylphenyl)piperazine1-(2-methylsulfanylphenyl)piperazine
3
1
PHOSPHATE IONPHOSPHATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303