7CQK: Cryo-EM structure of the substrate-bound SPT-ORMDL3 complex

PDB ID: 7CQKDownload
MMDB ID: 198623
PDB Deposition Date: 2020/8/11
Updated in MMDB: 2025/07
Experimental Method:
electron microscopy
Resolution: 3.3  Å
Source Organism:
Similar Structures:
Biological Unit for 7CQK: pentameric; determined by author
Molecular Components in 7CQK
Label Count Molecule
Proteins (5 molecules)
2
Serine Palmitoyltransferase 1
(Gene symbol: SPTLC1)
Molecule annotation
1
Serine Palmitoyltransferase 2
(Gene symbol: SPTLC2)
Molecule annotation
1
Orm1-like Protein 3
(Gene symbol: ORMDL3)
Molecule annotation
1
Serine Palmitoyltransferase Small Subunit a
(Gene symbol: SPTSSA)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE
2
1
[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3R)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[2-(2-oxidanylideneheptadecylsulfanyl)ethylamino]propyl]amino]butyl] hydrogen phosphate[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3R)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[2-(2-oxidanylideneheptadecylsulfanyl)ethylamino]propyl]amino]butyl] hydrogen phosphate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303