7CBQ: Crystal structure of PDE4D catalytic domain in complex with Apremilast

PDB ID: 7CBQDownload
MMDB ID: 198022
PDB Deposition Date: 2020/6/13
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.59  Å
Source Organism:
Similar Structures:
Biological Unit for 7CBQ: dimeric; determined by author
Molecular Components in 7CBQ
Label Count Molecule
Proteins (2 molecules)
2
Camp-specific 3',5'-cyclic Phosphodiesterase 4D
(Gene symbol: PDE4D)
Molecule annotation
Chemicals and Non-standard biopolymers (18 molecules)
1
3
MAGNESIUM IONMAGNESIUM ION
2
2
ZINC IONZINC ION
3
11
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
2
N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamideN-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303