7C3G: Crystal structure of human ALK2 kinase domain with R206H mutation in complex with a bicyclic pyrazole inhibitor RK-73134

PDB ID: 7C3GDownload
MMDB ID: 199371
PDB Deposition Date: 2020/5/12
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.802  Å
Source Organism:
Similar Structures:
Biological Unit for 7C3G: monomeric; determined by author and by software (PISA)
Molecular Components in 7C3G
Label Count Molecule
Protein (1 molecule)
1
Activin Receptor Type-1
(Gene symbol: ACVR1)
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
1
~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{H}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{H}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine
2
10
SULFATE IONSULFATE ION
3
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303