7C2V: Crystal Structure of IRAK4 kinase in complex with the inhibitor CA-4948

PDB ID: 7C2VDownload
MMDB ID: 195675
PDB Deposition Date: 2020/5/9
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 2.44  Å
Source Organism:
Similar Structures:
Biological Unit for 7C2V: tetrameric; determined by author
Molecular Components in 7C2V
Label Count Molecule
Proteins (4 molecules)
4
Interleukin-1 Receptor-associated Kinase 4
(Gene symbol: IRAK4)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
4
2-(2-methylpyridin-4-yl)-N-[2-morpholin-4-yl-5-[(3R)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide2-(2-methylpyridin-4-yl)-N-[2-morpholin-4-yl-5-[(3R)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303