7BE5: Crystal structure of MAP kinase p38 alpha in complex with inhibitor SR276

PDB ID: 7BE5Download
MMDB ID: 199349
PDB Deposition Date: 2020/12/22
Updated in MMDB: 2022/09
Experimental Method:
x-ray diffraction
Resolution: 1.80005  Å
Source Organism:
Similar Structures:
Biological Unit for 7BE5: monomeric; determined by author
Molecular Components in 7BE5
Label Count Molecule
Protein (1 molecule)
1
Mitogen-activated Protein Kinase 14
(Gene symbol: Mapk14)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
2
1
5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-[[(3~{R})-1-methylsulfonylpiperidin-3-yl]amino]-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-methyl-pyrazole-4-carboxamide5-azanyl-~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-[[(3~{R})-1-methylsulfonylpiperidin-3-yl]amino]-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]-1-methyl-pyrazole-4-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303