7B5L: Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27-UBE2L3~Ub~ARIH1. Transition State 1

PDB ID: 7B5LDownload
MMDB ID: 198596
PDB Deposition Date: 2020/12/4
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3.8  Å
Source Organism:
Similar Structures:
Biological Unit for 7B5L: dodecameric; determined by author and by software (PISA)
Molecular Components in 7B5L
Label Count Molecule
Proteins (12 molecules)
1
Cullin-1
(Gene symbol: CUL1)
Molecule annotation
1
E3 Ubiquitin-protein Ligase Arih1
(Gene symbol: ARIH1)
Molecule annotation
1
S-phase Kinase-associated Protein 2
(Gene symbol: SKP2)
Molecule annotation
1
Cyclin-dependent Kinases Regulatory Subunit 1
(Gene symbol: CKS1B)
Molecule annotation
1
S-phase Kinase-associated Protein 1
(Gene symbol: SKP1)
Molecule annotation
1
Polyubiquitin-c
(Gene symbol: UBC)
Molecule annotation
1
Nedd8
(Gene symbol: NEDD8)
Molecule annotation
1
E3 Ubiquitin-protein Ligase Rbx1
(Gene symbol: RBX1)
Molecule annotation
1
Ubiquitin-conjugating Enzyme E2 L3
(Gene symbol: UBE2L3)
Molecule annotation
1
Cyclin-dependent Kinase 2
(Gene symbol: CDK2)
Molecule annotation
1
Cyclin-a2
(Gene symbol: CCNA2)
Molecule annotation
1
Cyclin-dependent Kinase Inhibitor 1B
(Gene symbol: CDKN1B)
Molecule annotation
Chemicals and Non-standard biopolymers (10 molecules)
1
9
ZINC IONZINC ION
2
1
5-azanylpentan-2-one5-azanylpentan-2-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303