7B0S: TRPC4 in complex with inhibitor GFB-8438

PDB ID: 7B0SDownload
MMDB ID: 196220
PDB Deposition Date: 2020/11/21
Updated in MMDB: 2024/05
Experimental Method:
electron microscopy
Resolution: 3.6  Å
Source Organism:
Similar Structures:
Biological Unit for 7B0S: tetrameric; determined by author and by software (PISA)
Molecular Components in 7B0S
Label Count Molecule
Proteins (4 molecules)
4
Transient Receptor Potential Cation Channel Subfamily C Member 4A
(Gene symbol: trpc4b)
Molecule annotation
Chemicals and Non-standard biopolymers (12 molecules)
1
4
5-chloranyl-4-[3-oxidanylidene-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]-1~{H}-pyridazin-6-one5-chloranyl-4-[3-oxidanylidene-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]-1~{H}-pyridazin-6-one
2
4
CALCIUM IONCALCIUM ION
3
4
(2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate(2R)-3-(phosphonooxy)propane-1,2-diyl dihexanoate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303