7AVQ: Crystal structure of haspin in complex with disubstituted imidazo[1,2- b]pyridazine inhibitor (compound 12)

PDB ID: 7AVQDownload
MMDB ID: 194770
PDB Deposition Date: 2020/11/5
Updated in MMDB: 2021/12
Experimental Method:
x-ray diffraction
Resolution: 1.65  Å
Source Organism:
Similar Structures:
Biological Unit for 7AVQ: monomeric; determined by author
Molecular Components in 7AVQ
Label Count Molecule
Protein (1 molecule)
1
Serine/threonine-protein Kinase Haspin
(Gene symbol: HASPIN)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
(2~{R})-2-[[3-(2~{H}-indazol-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol(2~{R})-2-[[3-(2~{H}-indazol-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino]butan-1-ol
2
1
SODIUM IONSODIUM ION
3
2
GLYCEROLGLYCEROL
4
1
(4S)-2-METHYL-2,4-PENTANEDIOL(4S)-2-METHYL-2,4-PENTANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303