7AK6: Cryo-EM structure of ND6-P25L mutant respiratory complex I from Mus musculus at 3.8 A

PDB ID: 7AK6Download
MMDB ID: 198256
PDB Deposition Date: 2020/9/29
Updated in MMDB: 2025/04
Experimental Method:
electron microscopy
Resolution: 3.82  Å
Source Organism:
Similar Structures:
Biological Unit for 7AK6: 45-meric; determined by author and by software (PISA)
Molecular Components in 7AK6
Label Count Molecule
Proteins (45 molecules)
1
Nadh-ubiquinone Oxidoreductase Chain 3
(Gene symbol: ND3)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 7, Mitochondrial
(Gene symbol: Ndufs7)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 3, Mitochondrial
(Gene symbol: Ndufs3)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 2, Mitochondrial
(Gene symbol: Ndufs2)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] Flavoprotein 2, Mitochondrial
(Gene symbol: Ndufv2)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] Flavoprotein 1, Mitochondrial
(Gene symbol: Ndufv1)
Molecule annotation
1
Nadh-ubiquinone Oxidoreductase 75 KDA Subunit, Mitochondrial
(Gene symbol: Ndufs1)
Molecule annotation
1
Nadh-ubiquinone Oxidoreductase Chain 1
(Gene symbol: ND1)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 8, Mitochondrial
(Gene symbol: Ndufs8)
Molecule annotation
1
Nadh-ubiquinone Oxidoreductase Chain 6
Molecule annotation
1
Nadh-ubiquinone Oxidoreductase Chain 4L
(Gene symbol: ND4L)
Molecule annotation
1
Nadh-ubiquinone Oxidoreductase Chain 5
(Gene symbol: ND5)
Molecule annotation
1
Nadh-ubiquinone Oxidoreductase Chain 4
(Gene symbol: ND4)
Molecule annotation
1
Nadh-ubiquinone Oxidoreductase Chain 2
(Gene symbol: ND2)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 10, Mitochondrial
(Gene symbol: Ndufa10)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 9, Mitochondrial
(Gene symbol: Ndufa9)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 4, Mitochondrial
(Gene symbol: Ndufs4)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 6, Mitochondrial
(Gene symbol: Ndufs6)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 2
(Gene symbol: Ndufa2)
Molecule annotation
2
Acyl Carrier Protein, Mitochondrial
(Gene symbol: Ndufab1)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 5
(Gene symbol: Ndufa5)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 6
(Gene symbol: Ndufa6)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 8
(Gene symbol: Ndufa8)
Molecule annotation
1
Mcg5603
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 13
(Gene symbol: Ndufa13)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 1
(Gene symbol: Ndufa1)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 3
(Gene symbol: Ndufa3)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Subunit C1, Mitochondrial
(Gene symbol: Ndufc1)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Subunit C2
(Gene symbol: Ndufc2)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] Iron-sulfur Protein 5
(Gene symbol: Ndufs5)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 1
(Gene symbol: Ndufb1-ps)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 11, Mitochondrial
(Gene symbol: Ndufb11)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 5, Mitochondrial
(Gene symbol: Ndufb5)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 6
(Gene symbol: Ndufb6)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 2, Mitochondrial
(Gene symbol: Ndufb2)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 3
(Gene symbol: Ndufb3)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 8, Mitochondrial
(Gene symbol: Ndufb8)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 4
(Gene symbol: Ndufb4)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 9
(Gene symbol: Ndufb9)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 7
(Gene symbol: Ndufb7)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Beta Subcomplex Subunit 10
(Gene symbol: Ndufb10)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 12
(Gene symbol: Ndufa12)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] 1 Alpha Subcomplex Subunit 7
(Gene symbol: Ndufa7)
Molecule annotation
1
Nadh Dehydrogenase [ubiquinone] Flavoprotein 3, Mitochondrial
(Gene symbol: Ndufv3)
Molecule annotation
Chemicals and Non-standard biopolymers (21 molecules)
1
6
IRON/SULFUR CLUSTERIRON/SULFUR CLUSTER
2
1
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
3
2
FE2/S2 (INORGANIC) CLUSTERFE2/S2 (INORGANIC) CLUSTER
4
1
FLAVIN MONONUCLEOTIDEFLAVIN MONONUCLEOTIDE
5
4
1,2-Distearoyl-sn-glycerophosphoethanolamine1,2-Distearoyl-sn-glycerophosphoethanolamine
6
2
CARDIOLIPINCARDIOLIPIN
7
1
ADENOSINE-5'-TRIPHOSPHATEADENOSINE-5'-TRIPHOSPHATE
8
1
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
9
1
ZINC IONZINC ION
10
2
~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303