7ACD: Crystal structure of the human METTL3-METTL14 complex with compound T30 (UZH1a)

PDB ID: 7ACDDownload
MMDB ID: 200250
PDB Deposition Date: 2020/9/10
Updated in MMDB: 2021/10
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 7ACD: monomeric; determined by author and by software (PISA)
Molecular Components in 7ACD
Label Count Molecule
Protein (1 molecule)
1
N6-adenosine-methyltransferase Catalytic Subunit
(Gene symbol: METTL3)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-oxidanyl-~{N}-[[(3~{R})-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-oxidanyl-~{N}-[[(3~{R})-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide
2
1
ACETATE IONACETATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303