7A3G: Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, 91

PDB ID: 7A3GDownload
MMDB ID: 203681
PDB Deposition Date: 2020/8/18
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 7A3G: dimeric; determined by author and by software (PISA)
Molecular Components in 7A3G
Label Count Molecule
Proteins (2 molecules)
2
Dipeptidyl Peptidase 8
(Gene symbol: DPP8)
Molecule annotation
Chemicals and Non-standard biopolymers (22 molecules)
1
4
trimethylamine oxidetrimethylamine oxide
2
2
~{N}-[3-(7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinolin-6-ylmethyl)phenyl]-2-ethyl-2-methanoyl-butanamide~{N}-[3-(7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinolin-6-ylmethyl)phenyl]-2-ethyl-2-methanoyl-butanamide
3
4
GLYCEROLGLYCEROL
4
8
PHOSPHATE IONPHOSPHATE ION
5
2
1-[3-(7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinolin-6-ylmethyl)phenyl]-3,3-diethyl-azetidine-2,4-dione1-[3-(7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinolin-6-ylmethyl)phenyl]-3,3-diethyl-azetidine-2,4-dione
6
2
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303