7A28: Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-617

PDB ID: 7A28Download
MMDB ID: 205768
PDB Deposition Date: 2020/8/16
Updated in MMDB: 2021/08
Experimental Method:
x-ray diffraction
Resolution: 1.89  Å
Source Organism:
Similar Structures:
Biological Unit for 7A28: monomeric; determined by author
Molecular Components in 7A28
Label Count Molecule
Protein (1 molecule)
1
Phosphodiesterase
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
1
1-cycloheptyl-3-(4-methoxy-3-{4-[4-(1H-1,2,3,4-tetrazol-5-yl)phenoxy]butoxy}phenyl)-4,4-dimethyl-4,5-dihydro-1H-pyrazol-5-one1-cycloheptyl-3-(4-methoxy-3-{4-[4-(1H-1,2,3,4-tetrazol-5-yl)phenoxy]butoxy}phenyl)-4,4-dimethyl-4,5-dihydro-1H-pyrazol-5-one
2
1
ZINC IONZINC ION
3
1
MAGNESIUM IONMAGNESIUM ION
4
2
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
5
5
GLYCEROLGLYCEROL
6
3
GUANIDINEGUANIDINE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303