6ZY5: Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 1

PDB ID: 6ZY5Download
MMDB ID: 202353
PDB Deposition Date: 2020/7/30
Updated in MMDB: 2021/06
Experimental Method:
electron microscopy
Resolution: 3.6  Å
Source Organism:
Similar Structures:
Biological Unit for 6ZY5: hexameric; determined by author and by software (PISA)
Molecular Components in 6ZY5
Label Count Molecule
Proteins (2 molecules)
2
DNA Topoisomerase 2-alpha
(Gene symbol: TOP2A)
Molecule annotation
Nucleotides(4 molecules)
2
DNA (5'-d(*cp*gp*cp*gp*cp*ap*tp*cp*gp*tp*cp*ap*tp*cp*cp*tp*c)-3')
Molecule annotation
2
DNA (5'-d(*gp*ap*gp*gp*ap*tp*gp*ap*cp*gp*ap*tp*g)-3')
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303