6ZXO: Crystal structure of His-tagged human thymidylate synthase (HT-hTS) in complex with FdUMP and Raltitrexed (Tomudex)

PDB ID: 6ZXODownload
MMDB ID: 202050
PDB Deposition Date: 2020/7/30
Updated in MMDB: 2021/05
Experimental Method:
x-ray diffraction
Resolution: 2.6  Å
Source Organism:
Similar Structures:
Biological Unit for 6ZXO: dimeric; determined by author and by software (PISA)
Molecular Components in 6ZXO
Label Count Molecule
Proteins (2 molecules)
2
Thymidylate Synthase
(Gene symbol: TYMS)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
TOMUDEXTOMUDEX
2
2
5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE
3
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303