6ZIS: Crystal structure of a CGRP receptor ectodomain heterodimer with bound high affinity inhibitor

PDB ID: 6ZISDownload
MMDB ID: 190228
PDB Deposition Date: 2020/6/26
Updated in MMDB: 2021/08
Experimental Method:
x-ray diffraction
Resolution: 1.73  Å
Source Organism:
Similar Structures:
Biological Unit for 6ZIS: monomeric; determined by author
Molecular Components in 6ZIS
Label Count Molecule
Protein (1 molecule)
1
Maltose/maltodextrin-binding Periplasmic Protein,receptor Activity-modifying Protein 1,calcitonin Gene-related Peptide Type 1 Receptor
(Gene symbol: RAMP1)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
alpha-D-glucopyranosealpha-D-glucopyranose
2
3
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
3
1
N-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl)carbonyl]pentyl}-3,5-dibromo-Nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3 (2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamideN-{(1S)-5-amino-1-[(4-pyridin-4-ylpiperazin-1-yl)carbonyl]pentyl}-3,5-dibromo-Nalpha-{[4-(2-oxo-1,4-dihydroquinazolin-3 (2H)-yl)piperidin-1-yl]carbonyl}-D-tyrosinamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303