6ZHO: Crystal structure of a CGRP receptor ectodomain heterodimer with bound high affinity inhibitor

PDB ID: 6ZHODownload
MMDB ID: 190227
PDB Deposition Date: 2020/6/23
Updated in MMDB: 2021/08
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 6ZHO: monomeric; determined by author and by software (PISA)
Molecular Components in 6ZHO
Label Count Molecule
Protein (1 molecule)
1
Maltose/maltodextrin-binding Periplasmic Protein,receptor Activity-modifying Protein 1,calcitonin Gene-related Peptide Type 1 Receptor
(Gene symbol: RAMP1)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
alpha-D-glucopyranosealpha-D-glucopyranose
2
1
~{N}-[(2~{R})-3-(7-methyl-2~{H}-indazol-5-yl)-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-piperidin-4-yl-1-(4-pyridin-4-ylpiperazin-1-yl)propan-2-yl]amino]propan-2-yl]-2-oxidanylidene-spiro[1~{H}-pyrido[2,3-d][1,3]oxazine-4,4'-piperidine]-1'-carboxamide~{N}-[(2~{R})-3-(7-methyl-2~{H}-indazol-5-yl)-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-piperidin-4-yl-1-(4-pyridin-4-ylpiperazin-1-yl)propan-2-yl]amino]propan-2-yl]-2-oxidanylidene-spiro[1~{H}-pyrido[2,3-d][1,3]oxazine-4,4'-piperidine]-1'-carboxamide
3
2
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303