6ZHC: PROTAC6 mediated complex of VHL:EloB:EloC and Bcl-xL

PDB ID: 6ZHCDownload
MMDB ID: 193024
PDB Deposition Date: 2020/6/22
Updated in MMDB: 2021/03
Experimental Method:
x-ray diffraction
Resolution: 1.92  Å
Source Organism:
Similar Structures:
Biological Unit for 6ZHC: tetrameric; determined by author and by software (PISA)
Molecular Components in 6ZHC
Label Count Molecule
Proteins (4 molecules)
1
VON Hippel-lindau Disease Tumor Suppressor
(Gene symbol: VHL)
Molecule annotation
1
Elongin-b
(Gene symbol: ELOB)
Molecule annotation
1
Elongin-c
(Gene symbol: ELOC)
Molecule annotation
1
Bcl-2-like Protein 1
(Gene symbol: BCL2L1)
Molecule annotation
Chemicals and Non-standard biopolymers (39 molecules)
1
1
2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]-5-[3-[4-[3-[2-[2-[2-[2-[2-[3-[[(2~{S})-3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-3-oxidanylidene-propoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-ynyl]phenoxy]propyl]-1,3-thiazole-4-carboxylic acid2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]-5-[3-[4-[3-[2-[2-[2-[2-[2-[3-[[(2~{S})-3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-3-oxidanylidene-propoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-ynyl]phenoxy]propyl]-1,3-thiazole-4-carboxylic acid
2
17
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
9
GLYCEROLGLYCEROL
4
12
IODIDE IONIODIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303