6ZF6: Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction

PDB ID: 6ZF6Download
MMDB ID: 200901
PDB Deposition Date: 2020/6/16
Updated in MMDB: 2021/05
Experimental Method:
x-ray diffraction
Resolution: 1.38  Å
Source Organism:
Similar Structures:
Biological Unit for 6ZF6: monomeric; determined by author and by software (PISA)
Molecular Components in 6ZF6
Label Count Molecule
Protein (1 molecule)
1
Kelch-like Ech-associated Protein 1
(Gene symbol: Keap1)
Molecule annotation
Chemicals and Non-standard biopolymers (19 molecules)
1
5
SULFATE IONSULFATE ION
2
13
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
3
1
1-[3-[2-hydroxy-2-oxoethyl(phenylsulfonyl)amino]phenyl]-5-[(1~{S},2~{S})-2-phenylcyclopropyl]pyrazole-4-carboxylic acid1-[3-[2-hydroxy-2-oxoethyl(phenylsulfonyl)amino]phenyl]-5-[(1~{S},2~{S})-2-phenylcyclopropyl]pyrazole-4-carboxylic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303