6ZF3: Keap1 kelch domain bound to a small molecule inhibitor of the Keap1-Nrf2 protein-protein interaction

PDB ID: 6ZF3Download
MMDB ID: 200898
PDB Deposition Date: 2020/6/16
Updated in MMDB: 2021/05
Experimental Method:
x-ray diffraction
Resolution: 1.28  Å
Source Organism:
Similar Structures:
Biological Unit for 6ZF3: monomeric; determined by author and by software (PISA)
Molecular Components in 6ZF3
Label Count Molecule
Protein (1 molecule)
1
Kelch-like Ech-associated Protein 1
(Gene symbol: Keap1)
Molecule annotation
Chemicals and Non-standard biopolymers (16 molecules)
1
1
~{N}-[3-[5-cyclopropyl-4-(2~{H}-1,2,3,4-tetrazol-5-yl)pyrazol-1-yl]phenyl]benzenesulfonamide~{N}-[3-[5-cyclopropyl-4-(2~{H}-1,2,3,4-tetrazol-5-yl)pyrazol-1-yl]phenyl]benzenesulfonamide
2
3
SULFATE IONSULFATE ION
3
12
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303