6ZBA: Crystal structure of PDE4D2 in complex with inhibitor LEO39652

PDB ID: 6ZBADownload
MMDB ID: 193835
PDB Deposition Date: 2020/6/8
Updated in MMDB: 2021/03
Experimental Method:
x-ray diffraction
Resolution: 1.6  Å
Source Organism:
Similar Structures:
Biological Unit for 6ZBA: tetrameric; determined by author and by software (PISA)
Molecular Components in 6ZBA
Label Count Molecule
Proteins (4 molecules)
4
Camp-specific 3',5'-cyclic Phosphodiesterase 4D
(Gene symbol: PDE4D)
Molecule annotation
Chemicals and Non-standard biopolymers (44 molecules)
1
4
2-methylpropyl 1-[8-methoxy-5-(1-oxidanylidene-3~{H}-2-benzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropane-1-carboxylate2-methylpropyl 1-[8-methoxy-5-(1-oxidanylidene-3~{H}-2-benzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropane-1-carboxylate
2
28
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
4
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
4
4
MAGNESIUM IONMAGNESIUM ION
5
4
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303