6YSK: 1-phenylpyrroles and 1-enylpyrrolidines as inhibitors of Notum

PDB ID: 6YSKDownload
MMDB ID: 192446
PDB Deposition Date: 2020/4/22
Updated in MMDB: 2020/09
Experimental Method:
x-ray diffraction
Resolution: 1.21  Å
Source Organism:
Similar Structures:
Biological Unit for 6YSK: monomeric; determined by author and by software (PISA)
Molecular Components in 6YSK
Label Count Molecule
Protein (1 molecule)
1
Palmitoleoyl-protein Carboxylesterase Notum
(Gene symbol: NOTUM)
Molecule annotation
Chemicals and Non-standard biopolymers (15 molecules)
1
1
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
4
SULFATE IONSULFATE ION
3
1
DIMETHYL SULFOXIDEDIMETHYL SULFOXIDE
4
8
1,2-ETHANEDIOL1,2-ETHANEDIOL
5
1
(3~{S})-1-[4-chloranyl-3-(trifluoromethyl)phenyl]pyrrolidine-3-carboxylic acid(3~{S})-1-[4-chloranyl-3-(trifluoromethyl)phenyl]pyrrolidine-3-carboxylic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303