6YG6: Crystal structure of MKK7 (MAP2K7) covalently bound with type-II inhibitor TL10-105

PDB ID: 6YG6Download
MMDB ID: 191227
PDB Deposition Date: 2020/3/27
Updated in MMDB: 2020/09
Experimental Method:
x-ray diffraction
Resolution: 2.15  Å
Source Organism:
Similar Structures:
Biological Unit for 6YG6: monomeric; determined by author
Molecular Components in 6YG6
Label Count Molecule
Protein (1 molecule)
1
Dual Specificity Mitogen-activated Protein Kinase Kinase 7
(Gene symbol: MAP2K7)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
2
1
~{N}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{S})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamide~{N}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{S})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303