6YDX: Insulin-regulated aminopeptidase complexed with a macrocyclic peptidic inhibitor

PDB ID: 6YDXDownload
MMDB ID: 190480
PDB Deposition Date: 2020/3/21
Updated in MMDB: 2025/12
Experimental Method:
x-ray diffraction
Resolution: 3.2  Å
Source Organism:
Similar Structures:
Biological Unit for 6YDX: monomeric; determined by author
Molecular Components in 6YDX
Label Count Molecule
Protein (1 molecule)
1
Leucyl-cystinyl Aminopeptidase
(Gene symbol: LNPEP)
Molecule annotation
Chemicals and Non-standard biopolymers (26 molecules)
1
18
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
1
beta-D-mannopyranosebeta-D-mannopyranose
3
1
2-[2-[[[(4~{R},8~{S},11~{S})-11-azanyl-8-[(4-hydroxyphenyl)methyl]-6,10-bis(oxidanylidene)-1,2-dithia-5,9-diazacyclotridec-4-yl]carbonylamino]methyl]phenyl]ethanoic acid2-[2-[[[(4~{R},8~{S},11~{S})-11-azanyl-8-[(4-hydroxyphenyl)methyl]-6,10-bis(oxidanylidene)-1,2-dithia-5,9-diazacyclotridec-4-yl]carbonylamino]methyl]phenyl]ethanoic acid
4
1
ZINC IONZINC ION
5
1
SUCCINIC ACIDSUCCINIC ACID
6
2
1,2-ETHANEDIOL1,2-ETHANEDIOL
7
1
PHOSPHATE IONPHOSPHATE ION
8
1
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303