6XVA: Crystal structure of the kinase domain of human c-KIT in complex with a type-II inhibitor bearing an acrylamide

PDB ID: 6XVADownload
MMDB ID: 188071
PDB Deposition Date: 2020/1/21
Updated in MMDB: 2020/06
Experimental Method:
x-ray diffraction
Resolution: 2.3  Å
Source Organism:
Similar Structures:
Biological Unit for 6XVA: monomeric; determined by author
Molecular Components in 6XVA
Label Count Molecule
Protein (1 molecule)
1
Mast/stem Cell Growth Factor Receptor Kit,mast/stem Cell Growth Factor Receptor KIT
(Gene symbol: KIT)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
~{N}-[[3-[2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanoylamino]-5-methyl-phenyl]methyl]propanamide~{N}-[[3-[2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanoylamino]-5-methyl-phenyl]methyl]propanamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303