6XK9: Cereblon in complex with DDB1, CC-90009, and GSPT1

PDB ID: 6XK9Download
MMDB ID: 195849
PDB Deposition Date: 2020/6/25
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 3.64  Å
Source Organism:
Similar Structures:
Biological Unit for 6XK9: trimeric; determined by author and by software (PISA)
Molecular Components in 6XK9
Label Count Molecule
Proteins (3 molecules)
1
Eukaryotic Peptide Chain Release Factor Gtp-binding Subunit Erf3a
(Gene symbol: GSPT1)
Molecule annotation
1
DNA Damage-binding Protein 1
(Gene symbol: DDB1)
Molecule annotation
1
Protein Cereblon
(Gene symbol: CRBN)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide
2
1
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303