6XFP: Crystal Structure of BRAF kinase domain bound to Belvarafenib

PDB ID: 6XFPDownload
MMDB ID: 199544
PDB Deposition Date: 2020/6/16
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 6XFP: dimeric; determined by author and by software (PISA)
Molecular Components in 6XFP
Label Count Molecule
Proteins (2 molecules)
2
Serine/threonine-protein Kinase B-raf
(Gene symbol: BRAF)
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
2
4-amino-N-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamide4-amino-N-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamide
2
11
CHLORIDE IONCHLORIDE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303