6XEV: CryoEM structure of GIRK2-PIP2/CHS - G protein-gated inwardly rectifying potassium channel GIRK2 with modulators cholesteryl hemisuccinate and PIP2

PDB ID: 6XEVDownload
MMDB ID: 206037
PDB Deposition Date: 2020/6/14
Updated in MMDB: 2024/12
Experimental Method:
electron microscopy
Resolution: 3.5  Å
Source Organism:
Similar Structures:
Biological Unit for 6XEV: tetrameric; determined by author
Molecular Components in 6XEV
Label Count Molecule
Proteins (4 molecules)
4
G Protein-activated Inward Rectifier Potassium Channel 2
(Gene symbol: Kcnj6)
Molecule annotation
Chemicals and Non-standard biopolymers (25 molecules)
1
4
[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
2
4
CHOLESTEROL HEMISUCCINATECHOLESTEROL HEMISUCCINATE
3
13
POTASSIUM IONPOTASSIUM ION
4
4
SODIUM IONSODIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303