6X86: Crystal Structure of TNFalpha with indolinone compound 11

PDB ID: 6X86Download
MMDB ID: 197434
PDB Deposition Date: 2020/6/1
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.93  Å
Source Organism:
Similar Structures:
Biological Unit for 6X86: trimeric; determined by author and by software (PISA)
Molecular Components in 6X86
Label Count Molecule
Proteins (3 molecules)
3
Tumor Necrosis Factor
(Gene symbol: TNF)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
3-[(6-{2-[(3R)-4-(hydroxyacetyl)-3-methylpiperazin-1-yl]pyrimidin-5-yl}-2,2-dimethyl-3-oxo-2,3-dihydro-1H-indol-1-yl)methyl]pyridine-2-carbonitrile3-[(6-{2-[(3R)-4-(hydroxyacetyl)-3-methylpiperazin-1-yl]pyrimidin-5-yl}-2,2-dimethyl-3-oxo-2,3-dihydro-1H-indol-1-yl)methyl]pyridine-2-carbonitrile
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303