6WXC: Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with potential repurposing drug Tipiracil

PDB ID: 6WXCDownload
MMDB ID: 187862
PDB Deposition Date: 2020
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.85  Å
Source Organism:
Similar Structures:
Biological Unit for 6WXC: hexameric; determined by author and by software (PISA)
Molecular Components in 6WXC
Label Count Molecule
Proteins (6 molecules)
6
Uridylate-specific Endoribonuclease
Molecule annotation
Chemicals and Non-standard biopolymers (51 molecules)
1
6
5-CHLORO-6-(1-(2-IMINOPYRROLIDINYL) METHYL) URACIL5-CHLORO-6-(1-(2-IMINOPYRROLIDINYL) METHYL) URACIL
2
6
PHOSPHATE IONPHOSPHATE ION
3
27
1,2-ETHANEDIOL1,2-ETHANEDIOL
4
12
FORMIC ACIDFORMIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303