6WW8: BRD4 Bromodomain 1 in complex with triple CDK4/6-PI3K-BET inhibitor

PDB ID: 6WW8Download
MMDB ID: 191738
PDB Deposition Date: 2020/5/8
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.302  Å
Source Organism:
Similar Structures:
Biological Unit for 6WW8: monomeric; determined by author and by software (PISA)
Molecular Components in 6WW8
Label Count Molecule
Protein (1 molecule)
1
Bromodomain-containing Protein 4
(Gene symbol: BRD4)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
7-cyclopentyl-N,N-dimethyl-2-({4-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide7-cyclopentyl-N,N-dimethyl-2-({4-[5-(morpholin-4-yl)-7-oxo-7H-thieno[3,2-b]pyran-3-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303