6WTQ: Human JAK2 JH1 domain in complex with PROTAC-intermediate linker handle 4

PDB ID: 6WTQDownload
MMDB ID: 201552
PDB Deposition Date: 2020/5/3
Updated in MMDB: 2021/12
Experimental Method:
x-ray diffraction
Resolution: 1.79968  Å
Source Organism:
Similar Structures:
Biological Unit for 6WTQ: monomeric; determined by author and by software (PISA)
Molecular Components in 6WTQ
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase Jak2
(Gene symbol: JAK2)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
N-methyl-4-{[4-(1-propyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}benzamideN-methyl-4-{[4-(1-propyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}benzamide
2
1
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
3
1
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303