6WTP: Human JAK2 JH1 domain in complex with PROTAC-intermediate linker handle 3

PDB ID: 6WTPDownload
MMDB ID: 201551
PDB Deposition Date: 2020/5/3
Updated in MMDB: 2021/12
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 6WTP: monomeric; determined by author and by software (PISA)
Molecular Components in 6WTP
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase Jak2
(Gene symbol: JAK2)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoatetert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoate
2
1
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303