6WS1: Crystal structure of human phenylethanolamine N-methyltransferase (PNMT) in complex with (2S)-2-amino-4-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(3-(7,8-dichloro-1,2,3,4-tetrahydroisoquinolin-4-yl)propyl)amino)butanoic

PDB ID: 6WS1Download
MMDB ID: 190864
PDB Deposition Date: 2020/4/30
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.76  Å
Source Organism:
Similar Structures:
Biological Unit for 6WS1: dimeric; determined by author and by software (PISA)
Molecular Components in 6WS1
Label Count Molecule
Proteins (2 molecules)
2
Phenylethanolamine N-methyltransferase
(Gene symbol: PNMT)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
1
S-ADENOSYL-L-HOMOCYSTEINES-ADENOSYL-L-HOMOCYSTEINE
2
3
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
1
CADMIUM IONCADMIUM ION
4
1
POTASSIUM IONPOTASSIUM ION
5
1
5'-([(3S)-3-amino-3-carboxypropyl]{3-[(4R)-7,8-dichloro-1,2,3,4-tetrahydroisoquinolin-4-yl]propyl}amino)-5'-deoxyadenosine5'-([(3S)-3-amino-3-carboxypropyl]{3-[(4R)-7,8-dichloro-1,2,3,4-tetrahydroisoquinolin-4-yl]propyl}amino)-5'-deoxyadenosine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303