6WOK: Crystal structure of estrogen receptor alpha in complex with receptor degrader 6

PDB ID: 6WOKDownload
MMDB ID: 189571
PDB Deposition Date: 2020/4/24
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.309  Å
Source Organism:
Similar Structures:
Biological Unit for 6WOK: dimeric; determined by author and by software (PISA)
Molecular Components in 6WOK
Label Count Molecule
Proteins (2 molecules)
2
Estrogen Receptor
(Gene symbol: ESR1)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
(2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol(2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol
2
1
(1R,3R)-1-(2,6-difluoro-4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-beta-carboline(1R,3R)-1-(2,6-difluoro-4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-beta-carboline
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303