6WNK: Macrocyclic peptides TDI5575 that selectively inhibit the Mycobacterium tuberculosis proteasome

PDB ID: 6WNKDownload
MMDB ID: 201328
PDB Deposition Date: 2020/4/22
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.28  Å
Source Organism:
Similar Structures:
Biological Unit for 6WNK: 28-meric; determined by author and by software (PISA)
Molecular Components in 6WNK
Label Count Molecule
Proteins (28 molecules)
14
Proteasome Subunit Alpha
Molecule annotation
14
Proteasome Subunit Beta
Molecule annotation
Chemicals and Non-standard biopolymers (36 molecules)
1
14
(12S,15S)-N-[(2-fluorophenyl)methyl]-10,13-dioxo-12-{2-oxo-2-[(2R)-2-phenylpyrrolidin-1-yl]ethyl}-2-oxa-11,14-diazatricyclo[15.2.2.1~3,7~]docosa-1(19),3(22),4,6,17,20-hexaene-15-carboxamide(12S,15S)-N-[(2-fluorophenyl)methyl]-10,13-dioxo-12-{2-oxo-2-[(2R)-2-phenylpyrrolidin-1-yl]ethyl}-2-oxa-11,14-diazatricyclo[15.2.2.1~3,7~]docosa-1(19),3(22),4,6,17,20-hexaene-15-carboxamide
2
14
CITRIC ACIDCITRIC ACID
3
8
DIMETHYLFORMAMIDEDIMETHYLFORMAMIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303