6WML: Human TLR8 bound to the potent agonist, GS-9688 (Selgantolimod)

PDB ID: 6WMLDownload
MMDB ID: 198179
PDB Deposition Date: 2020/4/21
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.5  Å
Source Organism:
Similar Structures:
Biological Unit for 6WML: dimeric; determined by author and by software (PISA)
Molecular Components in 6WML
Label Count Molecule
Proteins (2 molecules)
2
Toll-like Receptor 8
(Gene symbol: TLR8)
Molecule annotation
Chemicals and Non-standard biopolymers (27 molecules)
1
19
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
2
4
beta-D-mannopyranosebeta-D-mannopyranose
3
2
alpha-D-mannopyranosealpha-D-mannopyranose
4
2
(2R)-2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methylhexan-1-ol(2R)-2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methylhexan-1-ol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303