6WIH: N-terminal mutation of ISCU2 (L35H36) traps Nfs1 Cys loop in the active site of ISCU2 without metal present. Structure of human mitochondrial complex Nfs1-ISCU2(L35H36)-ISD11 with E.coli ACP1 at 1.9 A resolution (NIAU)2

PDB ID: 6WIHDownload
MMDB ID: 187616
PDB Deposition Date: 2020/4/9
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Homo sapiens▼
Similar Structures:
Biological Unit for 6WIH: tetrameric; determined by author
Molecular Components in 6WIH
Label Count Molecule
Proteins (4 molecules)
1
Cysteine Desulfurase, Mitochondrial
Molecule annotation
1
LYR Motif-containing Protein 4
Molecule annotation
1
Acyl Carrier Protein
Molecule annotation
1
Iron-sulfur Cluster Assembly Enzyme Iscu, Mitochondrial
Molecule annotation
Chemicals and Non-standard biopolymers (62 molecules)
1
1
PYRIDOXAL-5'-PHOSPHATEPYRIDOXAL-5'-PHOSPHATE
2
9
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
3
5
GLYCEROLGLYCEROL
4
38
1,2-ETHANEDIOL1,2-ETHANEDIOL
5
2
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
6
1
2,5,8,11,14,17-HEXAOXANONADECAN-19-OL2,5,8,11,14,17-HEXAOXANONADECAN-19-OL
7
3
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
8
1
{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID
9
1
S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioateS-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate
10
1
PENTAETHYLENE GLYCOLPENTAETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303