6WI2: Structure of human mitochondrial complex Nfs1-ISCU2-ISD11 with E.coli ACP1 at 1.95 A resolution (NIAU)2. N-terminal mutation of ISCU2 (L35) traps Nfs1 Cys loop in the active site of ISCU2 without metal present

PDB ID: 6WI2Download
MMDB ID: 186833
PDB Deposition Date: 2020/4/8
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 1.95  Å
Source Organism:
Homo sapiens▼
Similar Structures:
Biological Unit for 6WI2: tetrameric; determined by author
Molecular Components in 6WI2
Label Count Molecule
Proteins (4 molecules)
1
Cysteine Desulfurase, Mitochondrial
Molecule annotation
1
LYR Motif-containing Protein 4
Molecule annotation
1
Acyl Carrier Protein
Molecule annotation
1
Iron-sulfur Cluster Assembly Enzyme Iscu, Mitochondrial
Molecule annotation
Chemicals and Non-standard biopolymers (58 molecules)
1
1
PYRIDOXAL-5'-PHOSPHATEPYRIDOXAL-5'-PHOSPHATE
2
36
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
3
GLYCEROLGLYCEROL
4
10
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
5
2
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
6
1
2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL
7
1
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
8
1
2-(N-MORPHOLINO)-ETHANESULFONIC ACID2-(N-MORPHOLINO)-ETHANESULFONIC ACID
9
1
{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID{[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID
10
1
S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioateS-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate
11
1
PENTAETHYLENE GLYCOLPENTAETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303