6WHA: HTR2A bound to 25-CN-NBOH in complex with a mini-Galpha-q protein, beta/gamma subunits and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)

PDB ID: 6WHADownload
MMDB ID: 193144
PDB Deposition Date: 2020/4/7
Updated in MMDB: 2024/12
Experimental Method:
electron microscopy
Resolution: 3.36  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 6WHA: pentameric; determined by author
Molecular Components in 6WHA
Label Count Molecule
Proteins (5 molecules)
1
Soluble Cytochrome B562,5-hydroxytryptamine Receptor 2A Chimera
Molecule annotation
1
G Subunit Q (Gi2-mini-gq Chimeric)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Single FAB Chain (Svfv16)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
4-(2-{[(2-hydroxyphenyl)methyl]amino}ethyl)-2,5-dimethoxybenzonitrile4-(2-{[(2-hydroxyphenyl)methyl]amino}ethyl)-2,5-dimethoxybenzonitrile
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303