6WAA: K. pneumoniae Topoisomerase IV (ParE-ParC) in complex with DNA and compound 34 (7-[(1S,5R)-1-amino-3-azabicyclo[3.1.0]hexan-3-yl]-4-(aminomethyl)-1-cyclopropyl-3,6-difluoro-8-methylquinolin-2(1H)-one)

PDB ID: 6WAADownload
MMDB ID: 190146
PDB Deposition Date: 2020/3/24
Updated in MMDB: 2024/12
Experimental Method:
x-ray diffraction
Resolution: 3.2  Å
Source Organism:
Similar Structures:
Biological Unit for 6WAA: hexameric; determined by author and by software (PISA)
Molecular Components in 6WAA
Label Count Molecule
Proteins (2 molecules)
2
DNA Topoisomerase 4 Subunit B,dna Topoisomerase (Atp-hydrolyzing) Chimera
Molecule annotation
Nucleotides(4 molecules)
2
DNA (5'-d(*tp*tp*ap*cp*gp*tp*tp*gp*tp*ap*t)-3')
Molecule annotation
2
DNA (5'-d(*gp*ap*tp*cp*ap*tp*ap*cp*ap*ap*cp*gp*tp*ap*a)-3')
Molecule annotation
Chemicals and Non-standard biopolymers (11 molecules)
1
3
(4S)-2-METHYL-2,4-PENTANEDIOL(4S)-2-METHYL-2,4-PENTANEDIOL
2
5
MAGNESIUM IONMAGNESIUM ION
3
1
CHLORIDE IONCHLORIDE ION
4
2
7-[(1S,5R)-1-amino-3-azabicyclo[3.1.0]hexan-3-yl]-4-(aminomethyl)-1-cyclopropyl-3,6-difluoro-8-methylquinolin-2(1H)-one7-[(1S,5R)-1-amino-3-azabicyclo[3.1.0]hexan-3-yl]-4-(aminomethyl)-1-cyclopropyl-3,6-difluoro-8-methylquinolin-2(1H)-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303