6W9E: Crystal Structure of Human CDK9/cyclinT1 in complex with MC180295

PDB ID: 6W9EDownload
MMDB ID: 206030
PDB Deposition Date: 2020/3/22
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 3.1  Å
Source Organism:
Similar Structures:
Biological Unit for 6W9E: dimeric; determined by author and by software (PISA)
Molecular Components in 6W9E
Label Count Molecule
Proteins (2 molecules)
1
Cyclin-dependent Kinase 9
(Gene symbol: CDK9)
Molecule annotation
1
Cyclin-t1
(Gene symbol: CCNT1)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
2
(4-amino-2-{[(1S,2S,4R)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone(4-amino-2-{[(1S,2S,4R)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone
2
2
(4-amino-2-{[(1R,2R,4S)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone(4-amino-2-{[(1R,2R,4S)-bicyclo[2.2.1]heptan-2-yl]amino}-1,3-thiazol-5-yl)(2-nitrophenyl)methanone
3
1
PHOSPHATE IONPHOSPHATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303