6W3K: Structure of unphosphorylated human IRE1 bound to G-9807

PDB ID: 6W3KDownload
MMDB ID: 196135
PDB Deposition Date: 2020/3/9
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.08  Å
Source Organism:
Similar Structures:
Biological Unit for 6W3K: dimeric; determined by author
Molecular Components in 6W3K
Label Count Molecule
Proteins (2 molecules)
2
Serine/threonine-protein Kinase/endoribonuclease Ire1
(Gene symbol: ERN1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
2
4-[5-[2,6-bis(fluoranyl)phenyl]-2~{H}-pyrazolo[3,4-b]pyridin-3-yl]-2-(4-oxidanylpiperidin-1-yl)-1~{H}-pyrimidin-6-one4-[5-[2,6-bis(fluoranyl)phenyl]-2~{H}-pyrazolo[3,4-b]pyridin-3-yl]-2-(4-oxidanylpiperidin-1-yl)-1~{H}-pyrimidin-6-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303