6VUM: Structure of nevanimibe-bound human tetrameric ACAT1

PDB ID: 6VUMDownload
MMDB ID: 187597
PDB Deposition Date: 2020/2/16
Updated in MMDB: 2020/06
Experimental Method:
electron microscopy
Resolution: 3.67  Å
Source Organism:
Similar Structures:
Biological Unit for 6VUM: tetrameric; determined by author
Molecular Components in 6VUM
Label Count Molecule
Proteins (4 molecules)
4
Sterol O-acyltransferase 1
(Gene symbol: SOAT1)
Molecule annotation
Chemicals and Non-standard biopolymers (22 molecules)
1
4
OLEIC ACIDOLEIC ACID
2
10
CHOLESTEROLCHOLESTEROL
3
4
nevanimibenevanimibe
4
2
COENZYME ACOENZYME A
5
2
S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name)S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name)
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303