6VSW: Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORgt

PDB ID: 6VSWDownload
MMDB ID: 187596
PDB Deposition Date: 2020/2/12
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 3.202  Å
Source Organism:
Similar Structures:
Biological Unit for 6VSW: monomeric; determined by author and by software (PISA)
Molecular Components in 6VSW
Label Count Molecule
Protein (1 molecule)
1
Rar-related Orphan Receptor C
(Gene symbol: RORC)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
5-(2,3-dichloro-4-{[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl}phenyl)-4-(4-fluoropiperidine-1-carbonyl)-N-(2-hydroxy-2-methylpropyl)-1,3-thiazole-2-carboxamide5-(2,3-dichloro-4-{[(2S)-1,1,1-trifluoropropan-2-yl]sulfamoyl}phenyl)-4-(4-fluoropiperidine-1-carbonyl)-N-(2-hydroxy-2-methylpropyl)-1,3-thiazole-2-carboxamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303