6VCJ: Crystal structure of hsDHFR in complex with NADP+, DAP, and R-naproxen

PDB ID: 6VCJDownload
MMDB ID: 194400
PDB Deposition Date: 2019/12/21
Updated in MMDB: 2020/12
Experimental Method:
x-ray diffraction
Resolution: 2.34  Å
Source Organism:
Similar Structures:
Biological Unit for 6VCJ: monomeric; determined by author and by software (PISA)
Molecular Components in 6VCJ
Label Count Molecule
Protein (1 molecule)
1
Dihydrofolate Reductase
(Gene symbol: DHFR)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
PYRIMIDINE-2,4-DIAMINEPYRIMIDINE-2,4-DIAMINE
2
1
(2R)-2-(6-methoxynaphthalen-2-yl)propanoic acid(2R)-2-(6-methoxynaphthalen-2-yl)propanoic acid
3
1
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
4
1
FOLIC ACIDFOLIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303